paclitaxelloaded dqasomes uj day after tumor implantation fig tumor growth stealth mode lithium battery company inhibition study in nude mice implanted with human colon cancer cells the mean tumor volume from each group was blotted against the number of days each group involved animals for stealth mode lithium battery company clarity, error bars were omitted note that after weeks the dose, normalized for paclitaxel, was tripled in all treatment groups empty dqasomes do not show any impact on tumor growth, paclitaxelloaded dqasomes with paclitaxel and dequalinium concentrations identical to controls seem to inhibit the tumor growth by about correspondingly, the average tumor weight in the treatment group, after sacrificing the animals days, later was approximately stealth mode lithium battery company half of that in all controls although this result seems to suggest that dqasomes might indeed be able to increase the therapeutic potential of paclitaxel, the preliminary character of this stealth mode lithium battery company first in vivo study has to be emphasized experiments to optimize the treatment protocol are ongoing in the authors laboratory summary since their initial description in , dqasomes and dqasomelike vesicles stealth mode lithium battery company have been established as the first mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as small drug molecules towards mitochondria within stealth mode lithium battery company living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for the treatment of cancer and for stealth mode lithium battery company the therapy of a multitude of mitochondrial diseases acknowledgments i am grateful to prof v p torchilin for many is ibuprofen ok in early pregnancy helpful discussions and for his strong and continuous support of my work i also would like to stealth fifth brown coumadin clinic spokane mode lithium battery company sincerely thank my graduate students, gerard dsouza, shingming cheng, sarathi boddapati and eyad katrangi, whose experimental work has made the writing of this chapter possible i am obliged to the muscular dystrophy association tucson, az, the united mitochondrial disease foundation pittsburgh, pa, mitovec, inc boston, ma and northeastern university boston, ma for the financial support i received from these stealth mode lithium battery company organizations during the last four years references weissig v, lasch j, erdos g, meyer hw, rowe tc and hughes j dqasomes a novel potential drug and gene delivery system made from dequalinium pharm res � smith ra, porteous cm, gane am and murphy mp delivery of bioactive molecules to mitochondria in vivo proc natl acad sci usa murphy mp and smith ra drug delivery to mitochondria stealth mode lithium battery company the key to mitochondrial medicine adv drug del rev muratovska a, lightowlers rn, taylor rw, wilce ia and murphy mp targeting large molecules to mitochondria adv drug del rev szewczyk a and wojtczak l mitochondria as a pharmacological target pharmacol rev weissig v mitochondrialtargeted drug and dna delivery crit rev ther drug carr syst weissig v, cheng sm and dsouza g mitochondrial pharmaceutics mitochondrion weissig stealth mode lithium battery company v targeted drug delivery to mammalian stealth mode lithium battery company mitochondria in living cells exp opin stealth mode lithium battery company drug del weissig v, boddapati sv, dsouza ggm and cheng sm targeting stealth mode lithium battery company of low molecular weight drugs to mammalian mitochondria drug des rev de rosa m, gambacorta a and gliozi a structure, biosynthesis, and physico chemical properties of archaebacterial lipids microbiol rev gambacorta a, gliozi a and de rosa m archaeal lipids and stealth mode lithium battery company their biotechnological applications world j microbiol biotechnol weissig v, mogel hj, wahab m and lasch j computer simulations of dqasomes proc intl symp control rel bioact mater weissig v, lizano � and torchilin vp a micellar stealth mode lithium battery company delivery system for dequalinium � a lipophilic cationic drug with anticarcinoma activity stealth mode lithium battery company j lipos res weissig v, lizano c, ganellin cr and torchilin vp stealth mode lithium battery company dna binding cationic bolasomes with delocalized stealth mode lithium battery company charge center a structureactivity relationship study stp pharma sci chrzanowskalightowlers zm, lightowlers rn and turnbull dm gene therapy for mitochondrial dna defects is it possible?