paclitaxelloaded dqasomes uj day salbutamol sandoz after tumor implantation fig tumor growth inhibition study in nude mice implanted with human colon cancer cells the salbutamol sandoz mean tumor volume from each group salbutamol sandoz was blotted against the number of salbutamol sandoz days each group involved animals for clarity, error bars were omitted note that after weeks the dose, normalized salbutamol sandoz for paclitaxel, was tripled in all treatment groups empty dqasomes do not show any impact on tumor growth, paclitaxelloaded dqasomes with paclitaxel and dequalinium salbutamol sandoz concentrations identical to controls seem to inhibit the tumor growth by about correspondingly, the average tumor weight in the treatment group, after sacrificing the animals days, later was approximately salbutamol sandoz half of that in all controls although this result seems to suggest that dqasomes might indeed be able salbutamol sandoz to increase the therapeutic potential of salbutamol sandoz paclitaxel, the preliminary character of this first in vivo study has to be emphasized experiments to optimize the treatment protocol are ongoing in the authors laboratory summary since their initial salbutamol sandoz description in , dqasomes and dqasomelike vesicles salbutamol sandoz have been established as the first mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as small drug molecules towards mitochondria within living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for the treatment of cancer and for salbutamol sandoz the therapy of a multitude of salbutamol sandoz mitochondrial diseases acknowledgments i am grateful to prof v p torchilin for many helpful discussions and for his salbutamol sandoz strong and continuous support of my salbutamol sandoz work i also would like to sincerely thank my graduate students, gerard salbutamol sandoz dsouza, shingming cheng, sarathi boddapati and eyad katrangi, whose experimental work has salbutamol sandoz made the writing of this chapter salbutamol sandoz possible i am obliged to the salbutamol sandoz muscular dystrophy association tucson, az, the salbutamol sandoz united mitochondrial disease foundation pittsburgh, pa, salbutamol sandoz mitovec, inc boston, ma and northeastern salbutamol sandoz university boston, ma for the financial support i received from these organizations during the last four years references weissig v, lasch j, erdos g, meyer hw, rowe tc and hughes j dqasomes a lithium kidney problems novel potential drug and gene delivery system made salbutamol sandoz from dequalinium pharm res � smith salbutamol sandoz ra, porteous cm, gane am and murphy mp delivery of bioactive molecules to mitochondria in vivo proc natl acad sci usa murphy mp and smith ra drug delivery to mitochondria salbutamol sandoz the key to mitochondrial medicine adv salbutamol sandoz drug del rev muratovska a, lightowlers rn, taylor rw, wilce ia and murphy mp targeting large molecules salbutamol sandoz to mitochondria adv drug del rev szewczyk a and wojtczak l mitochondria as a pharmacological target pharmacol rev weissig v mitochondrialtargeted drug and dna delivery crit rev ther drug carr syst weissig v, cheng sm and salbutamol sandoz dsouza g mitochondrial pharmaceutics mitochondrion weissig salbutamol sandoz v targeted drug delivery to mammalian mitochondria in living cells exp opin drug del weissig v, boddapati sv, salbutamol sandoz dsouza ggm and cheng sm targeting salbutamol sandoz of low molecular weight drugs to salbutamol sandoz mammalian mitochondria drug des rev de rosa m, gambacorta a and gliozi salbutamol sandoz a structure, biosynthesis, and physico chemical properties of archaebacterial lipids microbiol rev gambacorta a, gliozi a and de rosa m archaeal lipids and their biotechnological applications world j microbiol biotechnol weissig v, mogel hj, wahab salbutamol sandoz m and lasch j computer simulations of dqasomes proc intl symp control rel bioact mater weissig v, lizano salbutamol sandoz � and torchilin vp a micellar delivery system for dequalinium � a salbutamol sandoz lipophilic cationic drug with anticarcinoma activity j lipos res weissig v, lizano c, ganellin cr and torchilin vp dna binding cationic bolasomes with delocalized charge center a structureactivity relationship study stp pharma sci chrzanowskalightowlers zm, lightowlers rn and turnbull dm gene therapy for mitochondrial dna defects is it possible?