� it the levels of iep, zn and changed after dialysis, due to the removal of molecules that were poorly linked mainly calan mai free peg at the outer part of the surface, allowing accessibility to the inner calan mai adjacent part of the shell water shell fig accessible layer to counter ions calan mai characterized by its thickness x and its dipolar charge density calan mai zn nm lnc presented the bestorganized and the accessible part of the shell, compared calan mai with other sizes of calan mai lnc, before and after dialysis calan mai lecithin was found to calan mai be present in the inner part of the polyelectrolyte layer and was found to play a role in the disorganization of the outer part calan mai dialyzing lnc formulated with lecithin led to stable and calan mai well structured nanocapsules, ready for an in vivo use calan mai as a olanzapine and dementia drug delivery system evaluation of complement system activation generally, after intravenous administration, nanoparticles np are rapidly removed from the blood stream calan mai because they are recognized by cells of the mps such as kiipffer cells in the liver, or spleen and calan mai bonemarrow macrophages however, a brush of peg chains grafted on the surface is known to decrease the recognition of nanoparticles by the immune system after intravenous administration one calan mai has demonstrated that a strong correlation prevails between the complement activation and the calan mai stealthy properties of lnc therefore, calan mai these properties were evaluated by measuring the degree of calan mai complement activation [ch technique and crossed immunoelectrophoresis c cleavage] and the level of macrophage calan mai uptake, in relation to the calan mai organization of peg chains, according to the electrokinetic properties calan mai of the lnc surface these experiments were performed on , and nm lnc before and calan mai after dialysis the ch technique is presented in fig calan mai nanoparticles are dispersed in human serum with sensitized erythrocytes after incubation, lysis is evaluated calan mai by a classical spectrophotometric method calan mai the measured absorbance is related to the consumption of complement proteins by particles the main conclusions are that whatever the in vitro test, all lnc were not recognized by the non specific components of the immune system it was probably due to the strong density of peg chains at their surface furthermore, dialysis maintains a sufficiently high density of peg and had no incidence on the complement consumption pharmacokinetic studies and biodistribution at first, the biodistribution of radiolabeled nanocapsules was studied by scintigraphy and � counting, after intravenous administration in rat whereby calan mai the mtcoxine was incorporated in the lipid core and i labelled the shell best narcotic combonations ultram of the nanocapsules dynamic scintigraphic acquisition was carried out hrs after administration and � activity in blood and tissues was calan mai followed for more than hrs see fig an early halfdisappearance time of about � min was found for i and � min for calan mai mtc these ranges of residence times were interesting for calan mai specific �a st active wcd�s calan mai vcub nnnnil scrum cdds vr i ?